![]() IC 50 values obtained from antiproliferative assay of each compound were 0.72 and 0.70 ug/ml respectively. Compound 1 and 2 were tested to assess antiproliferative activity of kaempferol and quercetin upon SP-C1tongue cancer cell. Results: Two compounds were produced consisting of kaempferol (1) and quercetin (2). Separation of bioactive compounds from Rasamala leaves ethyl acetate extract was using various chromatography techniques guided by antiproliferative assay. Methods: This is an experimental laboratory study using SP-C1 human tongue cancer cell. Objectives: to discover bioactive compounds of Rasamala leaves which possess an activity to inhibit SP-C1 human tongue cancer cell proliferation by reducing the expression of c-Myc proto oncogene. It is characterized by aggressive cell growth, poor prognosis and being the cause of mortality. Background : Tongue cancer is a common neoplasm found in oral cavity. ![]()
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